DARPP-32 | RuleBase

Chapters expand collapse

Introduction
- How to Use This cBook
- Intro to Neurotransmission
- About DARPP-32
- DARPP-32, Dopamine, & Glutamate
The Fernandez Model
- The Fernandez Article
- Translating the Fernandez Model
Agents
- DARPP-32
- CDK5
- CK1
- PP2A
- PP2B
- PP2C
- PDE
- cAMP
- Calcium
- PKAc
- PKAr1
- PKAr2
CK1 Phosphorylation
- CK1 Phosphorylation
- CK1.PP2B
- CK1@x_u
- CK1@x_p
PDE Phosphorylation
- PDE Phosphorylation
- PDE.PKAc
- PDE@x_p
- PDE@x_u
PP2A Phosphorylation
- PP2A Phosphorylation
- PP2A.PKAc
- PP2A@x_p
- PP2A@x_u
PP2B Activation
- PP2B Activation
- PP2B.Calcium2
- PP2B.Calcium4
PKA Activation
- PKA Activation
- PKAr1.PKAr2
- PKAr1.PKAr2.PKAc
- PKAr1.PKAr2.PKAc2
- PKAr.PKAc.cAMP
- PKAr.PKAc.cAMP2
- PKAr.PKAc.cAMP3
- PKAr.PKAc.cAMP4
- PKAr.cAMP4.PKAc2
- PKAr.cAMP4.PKAc
cAMP Degradation
- Degradation of cAMP
- cAMP.PDE
- cAMP@cyclic_no (PDE)
- cAMP.PDEP
- cAMP@cyclic_no (PDEP)
Calcium Synthesis/Degradation
- Calcium Synthesis & Degradation
- Calcium_syn
- Calcium_deg
DARPP-32@Thr34 Modifications
- DARPP-32@Thr34 Modifications
- DARPP-32.PKAc
- DARPP-32@T34_p
- DARPP-32(T34P).PP2B
- DARPP-32@T34_u
- DARPP-32(T75P).PKAc
- DARPP-32@T34_p (with T75P)
- DARPP-32(T34P,T75P).PP2B
- DARPP-32@T34_u (with T75P)
- DARPP-32(S137P).PKAc
- DARPP-32@T34_p (with S137P)
- DARPP-32(T34P,S137P).PP2B
- DARPP-32@T34_u (with S137P)
- DARPP-32(T75P,S137P).PKAc
- DARPP-32@T34_p (with T75P, S137P)
- DARPP-32(T34P,T75P,S137P).PP2B
- DARPP-32@T34_u (with T75P, S137P)
DARPP-32@Thr75 Modifications
- DARPP-32@Thr75 Modifications
- DARPP-32.CDK5
- DARPP-32@T75_p
- DARPP-32(T75P).PP2A
- DARPP-32@T75_u
- DARPP.32(T34P).CDK5
- DARPP-32@T75_p (with T34P)
- DARPP-32(T34P,T75P).PP2A
- DARPP-32@T75_u (with T34P)
- DARPP-32(S137P).CDK5
- DARPP-32@T75_p (with S137P)
- DARPP-32@(T75P,S137P).PP2A
- DARPP-32@T75_u (with S137P)
- DARPP-32(T34P,S137P).CDK5
- DARPP-32@T75_p (with T34P, S137P)
- DARPP-32(T34P,T75P,S137P).PP2A
- DARPP-32@T75_u (with T34P, S137P)
- DARPP-32(T75P).PP2AP
- DARPP-32@T75_u (PP2AP)
- DARPP-32(T34P,T75P).PP2AP
- DARPP-32@T75_u (with T34P) (PP2AP)
- DARPP-32(T75P,S137P).PP2AP
- DARPP-32@T75_u (with S137P) (PP2AP)
- DARPP-32(T34P,T75P,S137P).PP2AP
- DARPP-32@T75_u (with T34P, S137P) (PP2AP)
DARPP-32@Ser137 Modifications
- DARPP-32@Ser137 Modifications
- DARPP-32.CK1
- DARPP-32@S137_p
- DARPP-32@S137P.PP2C
- DARPP-32@S137_u
- DARPP-32(T34P).CK1
- DARPP-32@S137_p (with T34P)
- DARPP-32(T34P,S137P).PP2C
- DARPP-32@S137_u (with T34P)
- DARPP-32(T75P).CK1
- DARPP-32@S137_p (with T75P)
- DARPP-32(T75P,S137P).PP2C
- DARPP-32@S137_u (with T75P)
- DARPP-32(T34P,T75P).CK1
- DARPP-32@S137_p (with T34P, T75P)
- DARPP-32(T34P,T75P,S137P).PP2C
- DARPP-32@S137_u (with T34P, T75P)
PP2A Activation (Model B Suppl. Rules)
- Activation of PP2A
- PP2A.Calcium
- PP2ACa.PKAc
- PP2ACa@x_p
- PP2APCa...PKAc
- PP2AP.Calcium
- PP2AP@x_u
- DARPP-32(T34P,T75P).PP2ACa
- DARPP-32@T75_u (with T34P) (PP2ACa)
- DARPP-32(T34P,T75P,S137P).PP2ACa
- DARPP-32@T75_u (with T34P, S137P) (PP2ACa)
- DARPP-32(T75P).PP2ACa
- DARPP-32@T75_u (PP2ACa)
- DARPP-32(T75P,S137P).PP2ACa
- DARPP-32@T75_u (with S137P) (PP2ACa)
- DARPP-32(T34P,T75P).PP2APCa
- DARPP-32@T75_u (with T34P) (PP2APCa)
- DARPP-32(T34P,T75P,S137P).PP2APCa
- DARPP-32@T75_u (with T34P, S137P) (PP2APCa)
- DARPP-32(T75P).PP2APCa
- DARPP-32@T75_u (PP2APCa)
- DARPP-32(T75P,S137P).PP2APCa
- DARPP-32@T75_u (with S137) (PP2APCa)
Simulations
- Overview of the Simulations
- Steady State
- cAMP_create
- cAMP Pulse
- Calcium Spikes (Model A)
- Calcium Spikes (Model B)
- cAMP Pulse & Calcium Spikes (Model A)
- cAMP Pulse & Calcium Spikes (Model B)
Summary
- Summary of the Fernandez Model
- Extension of the Fernandez Model
G proteins
- Heterotrimeric G Proteins & GPCRs
- AC
- G-alpha_s
- G-alpha_i
- G-beta-gamma
- G-alpha_s.G-beta-gamma
- G-alpha_s@nuc_GTP
- G-alpha_s@nuc_GDP
- G-alpha_s@nuc_GDP (AC)
- G-alpha_s.AC
- G-alpha_i.G-beta-gamma
- G-alpha_i@nuc_GTP
- G-alpha_i@nuc_GDP
- G-alpha_i@nuc_GDP (AC)
- G-alpha_i.AC
- cAMP_synthesis (AC)
- cAMP_synthesis (AC-G-alpha_s)
- cAMP_synthesis (AC-G-alpha_i)
- cAMP_synthesis (AC-G-alpha_s/i)
Dopamine Receptors
- DA
- D1
- DA.D1
- D1.G-alpha_s
- G-alpha_s@nuc_GTP (D1)
- G-alpha_s@nuc_GTP (DA-D1)
- D2
- DA.D2
- D2.G-alpha_i
- G-alpha_i@nuc_GTP (D2)
- G-alpha_i@nuc_GTP (DA-D2)
- DA_create
- DA_deg
- cAMP Pulse w/D1 Receptor
Adenosine Receptors
- Adenosine
- A1
- Adenosine.A1
- A1.G-alpha_i
- G-alpha_i@nuc_GTP (A1)
- G-alpha_i@nuc_GTP (A-A1)
- A2A
- Adenosine.A2A
- A2A.G-alpha_s
- G-alpha_s@nuc_GTP (A2A)
- G-alpha_s@nuc_GTP (A-A2A)
Serotonin Receptors
- Serotonin
- 5-HT4
- Serotonin.5-HT4
- 5-HT4.G-alpha_s
- G-alpha_s@nuc_GTP (5-HT4)
- G-alpha_s@nuc_GTP (S-5-HT4)
- 5-HT1B
- Serotonin.5-HT1B
- 5-HT1B.G-alpha_i
- G-alpha_i@nuc_GTP (5-HT1B)
- G-alpha_i@nuc_GTP (S-5-HT1B)
Appendix
- History

DARPP-32

Foreword

This cBook demonstrates the crucial role of DARPP-32 as an integrator of dopamine and glutamate signals, providing insights into the mechanisms behind the regulation of DARPP-32. This interactive and collaborative cBook allows the readers to copy it and have an opportunity to explore the dynamic behavior of DARPP-32 signaling on their own using the library of agents, rules, and models.

To begin exploring the DARPP-32 cBook, click here.

Created

August 27th, 2009 by Vy Hoang